Pair Name	Caffeic acid phenethyl ester, Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Inhibition-->Lipid metabolism
Gene Regulation	Down-regulation	Expression	SREBF1	hsa6720
	Down-regulation	Expression	ACACA	hsa31
	Down-regulation	Expression	FASN	hsa2194
	Down-regulation	Expression	SCD	hsa6319
	Down-regulation	Phosphorylation	AKT1	hsa207
	Down-regulation	Phosphorylation	MTOR	hsa2475
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
Result	Our results suggest that CAPE treatment reversed DOX resistance in breast cancer cells, at least in part by inhibiting Akt/mTOR/SREBP1 pathway-mediated lipid metabolism, indicating that CAPE may be an effective substance to assist in the treatment of breast cancer.